Група за неуронауке бави се испитивањима механизама и биолошких корелата виших нервних функција. Испитивањима су обухваћени како здрави људи, тако и људи са различитим патолошким стањима централног нервног система (ЦНС). Примењују се различите методе из обаласти неурофизиологије и психофизиологије, неуропсихологије и психометрије, наука о спорту и сл.
У раду Групе посебан значај имају новоразвијене методе неинвазивне неуромодулације (МНН) за транскранијалну стимулацију помоћу магнетних импулса и електричног поља. Ове методе, са којима је Група стекла значајно искуство и међународну репутацију, омогућавају селективну и циљану модулацију неуралних кругова и система релевантних за стање на које се жели утицати. Активности Групе обухватају како употребу МНН за функционалну евалуацију и модулацију ексцитабилности, синаптичке активације и пластицитета ЦНС, тако и испитвање интеракција МНН и разних облика тренинга, физиотерапије и лекова.
Испитивањима су обухваћене различите популације болесника (са есктрапирамидалним болестима као што су Паркинсонова болест и дистонија, хроничним болом као и стањима после цереброваскуларних инсулта) и на репрезентативним популацијама здравих испитаника. Испитивања обухватају регистровање физиолошких параметара активности сензо-моторних система, психолошка тестирања, кинематичка мерења и одређивање промена до којих долази дејством МНН.
Код пацијента се такође утврђују и корелације ових налаза са клиничким параметрима. Добијени резултати, поред тога што доприносе бољем разумевању механизама дејства МНН, омогућавају боље разумевање механизама кортикалне ескцитабилности, активације и пластицитета као и њихових поремећаја. Резултати истраживања које Група спроводи би требало да доведу, с једне стране, до дефинисања оптималних параметара за употребу МНН у терапији, било самостално или ради побољшавања ефеката других облика лечења (лекови, рехабилитација) и спортског тренинга, а са друге стране, да омогуће идентификовање неурофизиолошких маркера резидуалног пластицитета код пацијената ради бољег дефинисања (персонализације) терапије.
Др Саша Филиповић, НСАВ (руководилац групе)
Др Милан Јелић, НСАР
Др Јасмина Вуксановић, НСАР
Др Јована Бјекић, НСАР
Урош Константиновић, ИП
Дуња Пауновић, ИП
Катарина Вулић, ИП
Марија Станковић, ИП
Сарадници Групе учествују у извођењу постдипломске наставе на другим факултетима Универзитета у Београду:
Медицински факултет
Биолошки факултет
Факултет спорта и физичког васпитања
Филозофски факултет, Психологија
Bilateral Scientific Collaboration: Scientific cooperation between Republic of Serbia and Republic of France – Programme “Pavle Savić” 2010-2011
Project Leader from Serbia: Saša Filipović, MD PhD, IMR
Project Leader from France: Prof. Jean-Pascal Lefaucheur, MD PhD, EA 4391 (Excitabilité Nerveuse et Thérapeutique), Université Paris 12
The collaboration’s aim is to foster collaboration in aphasia treatment research across Europe. It will have as one of the end products a tool (a battery of tests) for aphasia assessment adapted and validated for use across Europe in various languages and cultures.
Action Lead: Glasgow Caledonian University NMAHP Research Unit, Glasgow, United Kingdom, Professor Marian Brady, PhD.
Participants from IMR:
Project No.: EU – ISCH COST Action IS1208, 2013-2017, (http://www.cost.eu/COST_Actions/isch/Actions/IS1208 ; http://www.aphasiatrials.org/ ).
The collaboration will have as an end product a clinical bedside tool for pain assessment in patients with dementia and cognitive impairments (PAIC). The PAIC tool is aimed to be adapted and validated for use across Europe in order to facilitate common research and to be used in clinical/health care settings.
Action Lead: University of Bamberg, Physiological Psychology, Bamberg, Germany, Professor Stefan Lautenbacher, PhD.
Participant from IMR: Saša Filipović, MD PhD, Managing Committee member for Serbia.
Project No.: EU – ISCH COST Action TD1005, 2011-2015, (http://www.cost.eu/COST_Actions/isch/Actions/TD1005 ; http://www.cost-td1005.net/ ).
Project Leader: Saša Filipović, MD PhD – IMR
Ministry for Education, Science, and Technological Development of Republic of Serbia – Project Grant ON175012, 2011-2017
Vuksanović J, Milovanović T, Konstantinović L, Filipović SR.(2018). Effect of type of language therapy on expressive language skills in patients with post-stroke aphasia. Int J Lang Commun Disord. Jul;53(4):825-835. doi: 10.1111/1460-6984.12390.
Filipović SR, Rothwell JC, Bhatia K (2010b) Slow (1Hz) repetitive transcranial magnetic stimulation (rTMS) induces a sustained change in cortical excitability in patients with Parkinson’s disease. Clinical Neurophysiology 121:1129-1137.
Filipović SR, Rothwell JC, van de Warrenburg BP, Bhatia K (2009) Repetitive transcranial magnetic stimulation for levodopa‐induced dyskinesias in Parkinson's disease. Movement Disorders 24:246-253.
Fyndanis V, Lind M, Varlokosta S, Kambanaros M, Soroli E, Ceder K, Grohmann KK, Rofes A, Simonsen HG, Bjekić J (2017) Cross-linguistic adaptations of The Comprehensive Aphasia Test: Challenges and solutions. Clinical Linguistics & Phonetics 1-14.
Haman E, Łuniewska M, Hansen P, Simonsen HG, Chiat S, Bjekić J, Blažienė A, Chyl K, Dabašinskienė I, Engel de Abreu P (2017) Noun and verb knowledge in monolingual preschool children across 17 languages: Data from cross-linguistic lexical tasks (LITMUS-CLT). Clinical Linguistics & Phonetics 1-26.
Ilić NV, Dubljanin-Raspopović E, Nedeljković U, Tomanović-Vujadinović S, Milanović SD, Petronić-Marković I, Ilić TV (2016) Effects of anodal tDCS and occupational therapy on fine motor skill deficits in patients with chronic stroke. Restorative Neurology and Neuroscience 1-11.
Ilić NV, Sajić J, Mišković M, Krstić J, Milanović S, Vesović-Potić V, Ljubisavljević M, Ilić TV (2009) The efficacy of two protocols for inducing motor cortex plasticity in healthy humans–TMS study. Gen Physiol Biophys 28:228-234.
Jaric S, Blesic S, Milanovic S, Radovanovic S, Ljubisavljevic M, Anastasijevic R (1999a) Changes in movement final position associated with agonist and antagonist muscle fatigue. European journal of applied physiology and occupational physiology 80:467-471.
Filipović S, Ljubisavljević M, Svetel M, Milanović S, Kačar A, Kostić V (1997) Impairment of cortical inhibition in writer's cramp as revealed by changes in electromyographic silent period after transcranial magnetic stimulation. Neuroscience letters 222:167-170.
Jaric S, Milanovic S, Blesic S, Latash ML (1999b) Changes in movement kinematics during single-joint movements against expectedly and unexpectedly changed inertial loads. Human movement science 18:49-66.
Jarić S, Radovanović S, Milanović S, Ljubisavljević M, Anastasijević R (1997) A comparison of the effects of agonist and antagonist muscle fatigue on performance of rapid movements. European journal of applied physiology and occupational physiology 76:41-47.
Jelić MB (2013) Uticaj neinvazivne neuromodulacije motornog korteksa na motorno učenje. Универзитет у Београду, Факултет спорта и физичког васпитања.
Jelić MB, Filipović SR, Milanović SD, Stevanović VB, Konstantinović L (2017) Bilateral sequential motor cortex stimulation and skilled task performance with non-dominant hand. Clinical Neurophysiology 128:814-822.
Jelić MB, Milanović SD, Filipović SR (2015) Differential effects of facilitatory and inhibitory theta burst stimulation of the primary motor cortex on motor learning. Clinical Neurophysiology 126:1016-1023.
Jelić MB, Stevanović VB, Milanović SD, Ljubisavljević MR, Filipović SR (2013) Transcranial magnetic stimulation has no placebo effect on motor learning. Clinical Neurophysiology 124:1646-1651.
Jovanović MD, Milanović S, Pavlović A, Nedeljković A (2013) System for Measurement of Biomechanical Characteristics of the Fingers and Hands. INFOTEH-JAHORINA.
Kačar A, Filipović S, Kresojević N, Milanović S, Ljubisavljević M, Kostić V, Rothwell J (2013) History of exposure to dopaminergic medication does not affect motor cortex plasticity and excitability in Parkinson’s disease. Clinical Neurophysiology 124:697-707.
Konstantinović LM, Jelić MB, Jeremić A, Stevanović VB, Milanović SD, Filipović SR (2013) Transcranial application of near‐infrared low‐level laser can modulate cortical excitability. Lasers in surgery and medicine 45:648-653.
Kostic P, Novicic D, Blesic S, Vasiljevic Z, Milanovic J, Pavlovic S (2011) Semantic search engine as tool for clinical decision support in register for acute coronary syndrome. Telfor J 3:66-71
Krstic J, Buzadžic I, Milanovic SD, Ilic NV, Pajic S, Ilic TV (2014) Low-frequency repetitive transcranial magnetic stimulation in the right prefrontal cortex combined with partial sleep deprivation in treatment-resistant depression: a randomized sham-controlled trial. The journal of ECT 30:325-331.
Lefaucheur J-P, André-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH, Cantello RM, Cincotta M, de Carvalho M, De Ridder D (2014) Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clinical Neurophysiology 125:2150-2206.
Lind M, Fyndanis V, Balčiūnienė I, Bjekić J, Ceder K, Gavarró A, Grohmann K, Haaland-Johansen L, Jacquemot C, Johansson MB (2016) Cross-linguistic adaptations of The Comprehensive Aphasia Test. In: International Clinical Phonetics and Linguistics Association Conference.
Ljubisavljevic M, Cukic M, Kalauzi A, Filipovic S, Fatima I (2010) The effects of transcranial magnetic stimulation on electromyographic characteristics in primary writing tremor patients. Movement Disorders 25:S532.
Ljubisavljevic M, Kacar A, Milanovic S, Svetel M, Kostic VS (2006) Changes in cortical inhibition during task‐specific contractions in primary writing tremor patients. Movement disorders 21:855-859.
Ljubisavljevic M, Maxood K, Bjekic J, Oommen J, Nagelkerke N (2016) Long-Term Effects of Repeated Prefrontal Cortex Tanscranial Direct Current Stimulation (tDCS) on Food Craving in Normal and Overweight Young Adults. BRAIN STIMULATION 9:826-833.
Ljubisavljevic M, Maxood K, Oommen J, Szolics M, Filipovic S (2015) Effects of bilateral pre-frontal tDCS stimulation on motor performance in elderly subjects. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation 8:398.
Ljubisavljević M, Kalezić I, Radovanović S, Milanović S, Blesić S, Anastasijević R (1998) Changes in fusimotor activity during repetitive lengthening muscle contractions in decerebrate cats. Neuroscience 86:1337-1342.
Ljubisavljević M, Vukčević I, Radovanović S, Milanović S, Anastasijević R (1997) Effects of cutaneous afferent input on fatigue-induced changes in fusimotor activity of decerebrate cats. Neuroscience 79:935-942.
Mancic B, Stevanovic I, Ilic TV, Djuric A, Stojanovic I, Milanovic S, Ninkovic M (2016) Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex. Neurochemistry international 100:120-127.
Milanovic S, Blesic S, Jaric S (2000) Changes in movement variables associated with transient overshoot of the final position. Journal of motor behavior 32:115-120.
Milanović S, Filipović S, Blesić S, Ilić T, Dhanasekaran S, Ljubisavljević M (2011) Paired-associative stimulation can modulate muscle fatigue induced motor cortex excitability changes. Behavioural brain research 223:30-35.
Milanović S, Filipović SR, Radovanović S, Blesić S, Ilić NV, Kostić VS, Ljubisavljević MR (2013) Changes in motor cortex excitability associated with muscle fatigue in patients with Parkinson's disease. Vojnosanitetski pregled 70:298-303.
Milanović S, Jovović Đ, Mihailović-Stanojević N, Grujić-Milanović J, Ivanov M, Karanović D, Miloradović Z (2012b) Uticaj hronične promene vrednosti hematokrita na krvni pritisak i glomerulsku filtraciju kod pacova sa urođenom hipertenzijom. Acta veterinaria 62:27-37.
Milanović S, Milanović S (2012) Host plant effect on the number of moultings and head capsule width of the gypsy moth caterpillars. Glasnik Sumarskog fakulteta 127-138.
Miloradovic ZMZ, Jovovic ĐJĐ, Mihailovic-Stanojevic NM-SN, Milanovic JGMJ, Milanovic SMS (2008) Effects of long-term losartan and l-arginine treatment on haemodynamics, glomerular filtration, and SOD activity in spontaneously hypertensive rats This article is one of a selection of papers published in the special issue Bridging the Gap: Where Progress in Cardiovascular and Neurophysiologic Research Meet. Canadian journal of physiology and pharmacology 86:210-214.
Miloradović Z, Gvozdenov M, Jovović Đ, Mihailović-Stanojević N, Ivanov M, Vajić UJ, Karanović D, Milanović SD, Grujić-Milanović J (2013) Effect of Olea europea L. leaf extract on haemodynamic status and lipid peroxidation in spontaneously hypertensive rats. Veterinarski glasnik 67:303-315.
Mirkov DM, Milanovic S, Ilie DB, Jaric S (2002) Symmetry of discrete and oscillatory elbow movements: Does it depend on torque that the agonist and antagonist muscle can exert? Motor Control 6:271-281.
Mirkov DM, Nedeljkovic A, Milanovic S, Jaric S (2004) Muscle strength testing: evaluation of tests of explosive force production. European journal of applied physiology 91:147-154.
Perovic A, Vuksanović J, Petrović B, Avramović-Ilić I (2014) The acquisition of passives in Serbian. Applied Psycholinguistics 35:1-26.
Plavšić B, Nedić D, Mićović Z, Tešić M, Stanojević S, Ašanin R, Krnjaić D, Tajdić N, Milanović S (2009) Veterinary information management system (VIMS) in the process of notification and management of animal diseases. Acta veterinaria 59:99-108.
Povše-Ivkić V, Krstić NS, Radosavljev J, Vidović P, Vuksanović JR (2002) Neurocognitive development in younger school children (II): Language abilities. Psihijatrija danas 34:275-290.
Povše Ivkić V, Krstić N, Radosavljev J, Vidović P (2002) i Vuksanović, J.(2002). Neurokognitivni razvoj kod dece mlađeg školskog uzrasta (II): jezičke sposobnosti. Psihijatrija danas 3:275-290.
R Ljubisavljevic M, Y Ismail F, Filipovic S (2013) Transcranial Magnetic Stimulation of Degenerating Brain: A Comparison of Normal Aging, Alzheimer’s, Parkinson’s and Huntington's Disease. Current Alzheimer Research 10:578-596
Radovanović S, Jarić S, Milanović S, Vukčević I, Ljubisavljević M, Anastasijević R (1998) The Effexts of Prior Antagonist Muscle Vibration on Performance of Rapid Movements. Journal of electromyography and kinesiology 8:139-145.
Rofesº A, Zakariás L, Cederº K, Lindºº M, Johansson MB, Orellana CM, Meteyardº L, Salmons I, Söré I, Lukács Á (2016) Word imageability from a cross-linguistic perspective.
Spasojević S, Ilić T, Milanović S, Potkonjak V, Rodić A, Santos-Victor J (2017) Combined Vision and Wearable Sensors-based System for Movement Analysis in Rehabilitation. Methods of information in medicine 56:95-111.
Vasiljevic-Pokrajcic Z, Mickovski N, Davidovic G, Asanin M, Stefanovic B, Krljanac G, Radosavljevic-Radovanovic M, Radovanovic N, Lasica R, Milanović S (2016) Sex and age differences and outcomes in acute coronary syndromes. International Journal of Cardiology 217:S27-S31.
Vasiljević Z, Dimković N, Lazarević K, Burmazović S, Krstić N, Milanović S, Zorić S, Micić D (2013) Postmarketing study of efficacy and safety of losartan during the treatment of patients with mild and moderate hypertension: Lothar study. Srpski arhiv za celokupno lekarstvo 141:22-28.
Vukovic M, Vuksanovic J, Vukovic I (2008) Comparison of the recovery patterns of language and cognitive functions in patients with post-traumatic language processing deficits and in patients with aphasia following a stroke. Journal of communication disorders 41:531-552.
Vuksanovic J, Bjekic J (2013) Developmental relationship between language and joint attention in late talkers. Research in developmental disabilities 34:2360-2368.
Vuksanovic J, Radivojevic N, Milanovic S, Konstantinovic L, Ilic IA, Avramovic I, Dragin A, Filipovic S, Jelic M, Jeremic A (2012) Effect of cortical activity neuromodulation on language recovery: A case study. International Journal of Psychology 47:572.
Vuksanovic JR (2015) Relationship between social interaction bids and language in late talking children. International journal of speech-language pathology 17:527-536.
Vuksanović J, Avramović-Ilić I, Bjekić J (2012) Comprehension of exhaustive wh-questions of typically developing preschool children. Zbornik Instituta za pedagoska istrazivanja 44:368-384.
Vuksanović J, Bjekić J, Radivojević N (2015a) Grammatical gender and mental representation of object: The case of musical instruments. Journal of psycholinguistic research 44:383-397.
Vuksanović J, Đurić M (2008a) The appropriacy of fluency tests in assessing epileptic seizure lateralization in children with partial epilepsy. Psihologija 41:195-211.
Vuksanović J, Đurić M (2008b) Prikladnost testova fluentnosti za procenu lateralizovanosti epileptičnog žarišta kod dece sa parcijalnom epilepsijom. Psihologija 41:195-211.
Vuksanović J, Jelić MB, Milanović SD, Kačar K, Konstantinović L, Filipović SR (2015b) Improvement of language functions in a chronic non-fluent post-stroke aphasic patient following bilateral sequential theta burst magnetic stimulation. Neurocase 21:244-250.
Vuksanović J, Jovanović A, Avramović-Ilić I, Petrović B (2008) Some indicators of (un) successful reading. Psihologija 41:343-355.
Vuksanović J, Petrović B, Avramović-Ilić I (2010) Applying of the Rey-Osterrieth Complex Figure Test in younger school children: Long-term memory indicators. Psihijatrija danas 42:5-16.
Vuksanović JR, Vuković MG, Đurić ML, Martinović ŽJ (2003) Characteristics of visual organization in children with partial epilepsy. Medicus 4:39-45.
Živanović M, Čerović S, Bjekić J (2017) A six-factor model of brand personality and its predictive validity.
Živanović M, Đokić T, Lazarević LB, Orlić A, Bjekić J (2014) Konstrukcija i empirijska provera testa homofobije. Primenjena psihologija 7:581-598.
Filipović SR, Rothwell JC, Bhatia K (2010a) Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson's disease. Journal of the neurological sciences 291:1-4.
Filipović SR, Bhatia KP, Rothwell JC (2013) 1‐Hz repetitive transcranial magnetic stimulation and diphasic dyskinesia in Parkinson's disease. Movement Disorders 28:245-245.
Filipović SR (2012b) Functional anatomy of dystonia–Getting the higher definition picture. Elsevier.
Filipović S, Jelić M, Milanović S, Stevanović V, Konstantinović L (2015) Comparative effectiveness of facilitatory NIBS methods in improving performance of a complex motor task. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation 8:391.
Filipović S (2014) Reply to “Motor cortex plasticity and excitability in Parkinson’s disease”. Clinical Neurophysiology 125:2136-2137.
Filipović S (2012a) Dystonia–a disorder of dynamics of brain plasticity modulation? Acta Physiologica 206:160-163.
Filipovic S, Kresojevic N, Kacar A, Petrovic I, Ljubisavljevic M, Kostic V (2010b) Intermittent theta burst stimulation improves bradykinesia in Parkinson's disease-preliminary results. Movement Disorders 25:S217.
Filipovic S, Kresojevic N, Kacar A, Petrovic I, Dragasevic N, Ljubisavljevic M, Kostic V (2010a) Can intermittent theta burst stimulation (itbs) improve speed and dexterity in Parkinson's disease? European Journal of Neurology 17:404.
Filipovic S, Kacar A, Milanovic S, Kresojevic N, Dragasevic N, Ljubisavljevic M, Kostic V (2011b) Dynamics of motor cortex excitability change during repetitive paired peripheral median nerve and Tms motor cortex stimulation (pas25 protocol)-Lack of short-latency afferent inhibition effect in de-novo drug-naive Parkinson's disease patients. Movement Disorders 26:S268-S269.
Filipovic S, Kacar A, Kresojevic N, Svetel M, Ljubisavljevic M, Kostic V (2011a) Drug-naive Parkinson's disease patients have normal plasticity and impaired short-latency intracortical inhibition in the motor cortex. Movement Disorders 26:S268.
Filipovic S, Kacar A, Kresojevic N, Svetel M, Ljubisavljevic M, Kostic V (2009) Sensorimotor cortical plasticity in drug-naïve Parkinson's disease patients. European Journal of Neurology 16:561.
Drljačić D, Pajić S, Nedeljković A, Milanović SD, Ilić T (2016) Complex modulation of fingertip forces during precision grasp and lift after theta burst stimulation over the dorsal premotor cortex. Vojnosanitetski pregled 249-249.
Dragasević N, Filipović S, Svetel M, Milanović S, Kostić V (1998) Clinical features of essential tremor. Srpski arhiv za celokupno lekarstvo 127:301-304.
Defrin R, Amanzio M, de Tommaso M, Dimova V, Filipovic S, Finn DP, Gimenez-Llort L, Invitto S, Jensen-Dahm C, Lautenbacher S (2015) Experimental pain processing in individuals with cognitive impairment: current state of the science. Pain 156:1396-1408.
Blesic S, Maric J, Dragasevic N, Milanovic S, Kostic V, Ljubisavljevic M (2011) Scaling analysis of bilateral hand tremor movements in essential tremor patients. Journal of Neural Transmission 118:1227-1234.
Bjekić JI (2016) Stilističke i sadržinske karakteristike verbalne produkcije kao indikatori bazične strukture ličnosti. Универзитет у Београду, Филозофски факултет.
Bjekić J, Živanović M, Purić D, Oosterman JM, Filipović SR (2017) Pain and executive functions: a unique relationship between Stroop task and experimentally induced pain. Psychological Research 1-10.
Bjekić J, Lazarević LB, Živanović M, Knežević G (2014) Psychometric evaluation of the Serbian dictionary for automatic text analysis-LIWCser. Psihologija 47:5-32.
Bjekić J, Lazarević L, Erić M, Stojimirović E, Đokić T (2012) Development of Serbian dictionary for automatic text analysis (LIWCser). Psihološka istraživanja 15:85-110.